克罗米酚对男性更高促性腺素性功能减退症有效

美国纽约（早些时候健康台湾版）1月末四日报道：据发表在12月末出台湾版的《生育与不育》杂志的一项统计数据指出克罗米胺对之外低促性腺效进行性减退的成人患儿薄弱。来自伯明罕肯塔基该大学的该统计数据的第一作者Scott J. WhittenDr在接受路透通讯社美联社说：“原发性或获得性HH患儿在接受侵害性较大和更为价格昂贵的放射治疗（例如针头促性腺激效类）以前进行4个月末的克罗米胺除此以外放射治疗是薄弱的。”WhittenDr和同事研究工作了克罗米胺对10名HH成人患儿（HH是加剧成人不育的少见因效）应该理论上。统计数据称克罗米胺放射治疗1年后，4名卡尔曼(氏)综合征患儿中只有一名患儿的精子含量减低而全垂体功能减退症患儿的精子缺乏症状均并未得到强化。相反，该统计数据指出3名成年得病的原发性HH成人患儿经过3个月末克罗米胺的放射治疗精子含量有了明显减低。目以前为止该组患儿已有两名恢复了后生。WhittenDr说：“除非对克罗米胺放射治疗并未反应，我们就会因为副作用停止对患儿使用该类固醇。”最后作者说明了说：“因为状况实际，对HH患儿促性腺激效类类固醇和克罗米胺的随机研究工作难以进行，然而利用多系列的严格选择标准对患儿进行分级可能希望必要性验证克罗米胺恢复成人低后生的实证。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色幻想

编辑： 张靖